Khi đã nắm được cơ cấu giải thưởng của xổ số miền Nam rồi, người chơi sẽ phải tìm hiểu những phương thức chơi xổ số sao cho có hiệu quả nhiều nhất. Có rất nhiều những phương thức chơi khác nhau trong đó nhiều người sử dụng phương pháp Soi cầu miền Nam.

Trong những cách soi cầu miền Nam có nhiều kiểu soi khác nhau, nhưng nhiều người chọn soi cầu kẹp khi có một số kẹp giữa số đầu và số cuối giống nhau. Xổ số kiến thiết miền Nam phát hành và quay thưởng từ 16h15 phút đến 16h30 phút hàng ngày. Nắm được khung giờ quay của xổ số minh ngọc miền nam sẽ giúp cho người chơi có nhiều chủ động hơn.

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